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Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Rege­ne­ra­tive The­ra­pies Dres­den (CRTD), junior rese­arch group Rege­ne­ra­tion of com­plex struc­tu­res in adult ver­te­bra­tes

The TU Dres­den is one of ele­ven Ger­man uni­ver­si­ties that were iden­ti­fied as an “excel­lence uni­ver­sity”. TUD has about 36.500 stu­dents and almost 5319 employees, 507 pro­fes­sors among them, and, thus, is the lar­gest uni­ver­sity in Sax­ony, today.

Having been com­mit­ted to sci­en­ces and the engi­nee­ring before the reuni­fi­ca­tion of Ger­many, TU Dres­den now is a multi-disci­pline uni­ver­sity, also offe­ring huma­nities and social sci­en­ces as well as medi­cine.

Rese­arch Asso­ciate / Post­doc

The Cen­ter for Rege­ne­ra­tive The­ra­pies Dres­den (CRTD), an insti­tute of the Cen­ter for Mole­cu­lar and Cel­lu­lar Bio­en­gi­nee­ring, is one of the lea­ding cen­tres for Rege­ne­ra­tive Medi­cine in the world. It is the inter­face bet­ween fun­da­men­tal rese­arch and cli­ni­cal app­li­ca­tion. The tar­get of the CRTD is to explore the self-hea­ling poten­tial of the body and to deve­lop com­ple­tely new rege­ne­ra­tive the­ra­pies for pre­viously incura­ble disea­ses. The rese­arch focu­ses are Hae­ma­to­logy and Immu­no­logy, Dia­be­tes, Neu­ro­de­ge­ne­ra­tive Disea­ses, Osteochon­dral repla­ce­ment, Car­dio­vas­cu­lar Disea­ses. The­r­eby, one of the core tasks is the tech­no­logy trans­fer that is rea­li­sed through a com­plex tech­no­logy plat­form. Here you can find more infor­ma­tion about the tech­no­logy plat­forms http://biotp.tudresden.de/biotechnology-platform/
The junior rese­arch group of Dr Maxi­mina Yun, Rege­ne­ra­tion of com­plex struc­tu­res in adult ver­te­bra­tes is offe­ring a posi­tion, star­ting as soon as pos­si­ble as
Rese­arch Asso­ciate / Post­doc (Sub­ject to per­so­nal qua­li­fi­ca­tion, employees are remu­n­e­ra­ted accord­ing to salary group E 13 TV-L).
The employ­ment con­tract is offe­red initi­ally until 31.12.2018 with a pos­si­bi­lity of exten­sion. The period of employ­ment is gover­ned by the Fixed Term Rese­arch Con­tracts Act (Wis­sen­schafts­zeit­ver­trags­ge­setz - Wiss­ZeitVG). The major aim of the group’s rese­arch pro­gramme is to under­stand the mole­cu­lar and cel­lu­lar mecha­nisms under­ly­ing rege­ne­ra­tion of com­plex struc­tu­res in adult ver­te­bra­tes, using sala­man­ders (newts and axo­lotls) as model orga­nisms. The group uses a broad range of cut­ting edge mole­cu­lar, gene­tic, bio­che­mi­cal and ima­ging tech­ni­ques to inves­ti­gate rege­ne­ra­tive pro­ces­ses. The can­di­date’s rese­arch pro­ject will focus on under­stan­ding the role and regu­la­tion of cel­lu­lar sene­scence during rege­ne­ra­tion of com­plex struc­tu­res (Yun et al, eLife, 2015; Davaa­pil et al, Deve­lop­ment 2017) with an empha­sis on the inter­play bet­ween cell sene­scence and the immune res­ponse.

Work­ing field:

Carry out expe­ri­men­tal rese­arch into the topic of how rege­ne­ra­tion of com­plex struc­tu­res is achie­ved in adult ver­te­bra­tes. This will be achie­ved through a com­bi­na­tion of tech­ni­ques inclu­ding sala­man­der (newt and axo­lotl) trans­ge­ne­sis, tis­sue cul­ture, expres­sion ana­ly­sis (RT-PCR, in situ hybri­di­sa­tion, RNA-seq), immu­n­o­histo­che­mis­try/fluo­re­scence, func­tio­nal stu­dies (small mole­cule tre­at­ments, CRISPR media­ted trans­gen­eis) and ima­ging. His/her duties will involve desi­gning and con­duc­ting expe­ri­ments, record­ing, ana­ly­sing and inter­pre­ting data, com­mu­ni­ca­ting results (writ­ten/oral) and acqui­ring appro­priate trai­ning accord­ing to the rese­arch pro­ject requi­re­ments; under­take rese­arch-rela­ted tasks to the stan­dards and objec­tives of the spe­ci­fic rese­arch pro­ject set by the Prin­ci­pal Inves­ti­ga­tor (Dr Maxi­mina Yun); actively par­ti­ci­pate in group mee­tings, mee­tings with aca­de­mic and non-aca­de­mic col­la­bo­ra­tors, record all work rela­ted data, pro­to­cols and pro­ject dis­cus­sions both elec­tro­ni­cally and in hard copy (Lab book); cont­ri­bute to the pro­duc­tion of rese­arch reports and publi­ca­ti­ons; pro­vide gui­dance/super­vi­sion as requi­red to other group mem­bers and stu­dents in rela­tion to rese­arch; cont­ri­bute to the over­all activi­ties of the rese­arch team and depart­ment as requi­red.

Require­ments:

Can­di­da­tes should be highly moti­va­ted with an uni­ver­sity degree and a PhD or equi­va­lent in Bio­lo­gi­cal or Bio­me­di­cal Sci­en­ces, who aim to deve­lop an inde­pen­dent rese­arch career. A strong back­ground in rege­ne­ra­tive bio­logy, cel­lu­lar sene­scence and/or immu­no­logy is requi­red. Expe­ri­ence in gene­tic engi­nee­ring, flow cyto­metry, RNA­seq/in situ hybri­di­sa­tion, sin­gle cell ana­ly­sis, ima­ging, bio­in­for­ma­tic ana­ly­sis and cell cul­ture are highly desi­ra­ble. Pre­vious expe­ri­ence working with sala­man­ders or other model sys­tems of rege­ne­ra­tion is desi­ra­ble but not essen­tial. Ability to work inde­pendently, show self-initia­tive and atten­tion to detail, and moti­va­tion to explore new tech­ni­ques and con­cepts are essen­tial. Excel­lent com­mu­ni­ca­tio­nal skills and flu­ency in Eng­lish are necessary to be con­side­red. While this posi­tion will be fun­ded by the group lea­der, post­doc­to­ral fel­lows are expec­ted to apply for their own exter­nal fel­lowship fun­ding.

What we of­fer:

Infor­mal enqui­ries should be direc­ted to Dr. Maxi­mina Yun (maximina.yun@tu-dresden.de).

How to ap­ply:

App­li­ca­ti­ons from women are par­ti­cu­larly wel­come. The same app­lies to people with disa­bi­li­ties.
We kindly ask you to send your app­li­ca­tion docu­ments (cover let­ter descri­bing publis­hed and ongo­ing work, CV, let­ter or con­tact for 3 refe­ren­ces, state­ment of future rese­arch inte­rest) until 05.01.2018 (stam­ped arri­val date app­lies) pre­fe­r­a­bly via the TU Dres­den Secu­re­Mail Por­tal https://securemail.tu-dresden.de by sen­ding it as a sin­gle pdf docu­ment to jana.fischer2@tu-dresden.de or to: TU Dres­den, CRTD, Frau Jana Fischer, Fet­scher­straße 105, 01307 Dres­den. Please sub­mit copies only, as your app­li­ca­tion will not be retur­ned to you. Expen­ses incur­red in atten­ding inter­views can­not be reim­bur­sed.