Technische Universität Dresden - Cluster of Excellence “Physics of Life” (PoL)
The TU Dresden is one of eleven German universities that were identified as an “excellence university”. TUD has about 36.500 students and almost 5319 employees, 507 professors among them, and, thus, is the largest university in Saxony, today.
Having been committed to sciences and the engineering before the reunification of Germany, TU Dresden now is a multi-discipline university, also offering humanities and social sciences as well as medicine.
Research Associate / PhD student
(subject to personal qualification employees are remunerated according to salary group E 13 TV-L)
The position is starting as soon as possible. The position is initially limited until August 31, 2024, which entails 65 % of the fulltime weekly hours, with the option of extension. The period of employment is governed by the Fixed Term Research Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG). The position aims at obtaining further academic qualification (e.g. PhD).
The goal of the project is to uncover biophysical mechanisms underlying patient-to-patient heterogeneity in tumor progression and drug response. The project will involve light microscopy and quantitative image analysis to characterize the cellular architecture and dynamic behavior of patient-derived tumor cell collectives. The project is funded by the German Cancer Aid from the Mildred-Scheel-Nachwuchszentrum Dresden and will benefit from collaborative interactions from various labs across the Dresden campus, including physicists, engineers, and physicians.
3D culturing of human gastrointestinal organoids in standard and novel matrices
Preparing samples for light microscopy, including immunofluorescence labelling and transient transfection of live fluorescent reporters
Generating stable fluorescently marked organoid lines with CRISPR
Performing 3D light microscopy
Quantitatively analyzing imaging data, such as cell segmentation and tracking
Regularly interacting with collaborators with expertise in physics and clinical medicine
Keeping pace with the relevant scientific literature
Presenting data in lab meetings, institutional seminars, and professional conferences
Contributing to the publication of scientific manuscripts on the research project
Keeping a detailed notebook documenting the research activities and writing interim status reports/evaluations.
university degree (Diplom/Master) in biology, medicine, physics, biophysics, or bioengineering. Students with a strong physics background wishing to apply their expertise to a biological problem with medical relevance, as well as students with a cancer biology or medical background wishing to learn quantitative, physical approaches, are particularly desired
strong interest in working in an interdisciplinary environment at the interface of physics, medicine, and cell biology
at least basic-level programming experience, particularly in Python and/or R
experience with advanced image analysis methods, machine learning, and/or physical modeling is desirable
good command of spoken and written English
excellent communication and presentation skills
high motivation to perform scientific research
ability and desire to work independently as well as together with others in a team
Experience in cell culture, in particular 3D organoid or spheroid culture, is advantageous.
What we offer:
Work in a collaborative, interdisciplinary environment
Exposure to world-class research through regular institute seminars and retreats
Mentorship for further career progression, including regular evaluations
Support for presentation in professional conferences.
How to apply:
Applications from women are particularly welcome. The same applies to people with disabilities. Please submit your application, including a detailed CV and a cover letter explaining your motivation to apply for this position, by May 4, 2021 (stamped arrival date applies) to TU Dresden, Exzellenzcluster PoL, z. Hdn. Frau Dr. Natalie Dye, Tatzberg 47 /49, 01307 Dresden or via the TU Dresden SecureMail Portal https://securemail.tu-dresden.de by sending it as a single pdf document to firstname.lastname@example.org, with the subject “Application for open PhD position/Dye”. Please submit copies only, as your application will not be returned to you. Expenses incurred in attending interviews cannot be reimbursed.
Reference to data protection: Your data protection rights, the purpose for which your data will be processed, as well as further information about data protection is available to you on the website: https: //tu-dresden.de/karriere/datenschutzhinweis