The mission of the Berlin Institute of Health (BIH) is medical translation: transferring biomedical research findings into novel approaches to personalized prediction, prevention, diagnostics and therapy and, conversely, using clinical observations to develop new research ideas. The aim is to deliver relevant medical benefits to patients and the population at large. The BIH is also committed to establishing a comprehensive translational ecosystem as translational research area at Charité – one that places emphasis on a system-wide understanding of health and disease and that promotes change in the biomedical research culture. The BIH is funded 90 percent by the Federal Ministry of Education and Research (BMBF) and 10 percent by the State of Berlin. The two founding institutions, Charité – Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), were independent member entities within the BIH until 2020. As of 2021, the BIH has been integrated into Charité as the so-called third pillar; the MDC is privileged partner of the BIH.
The Stem Cell Core Facility and the Core Unit Bioinformatics (CUBI) of the BIH are looking for a Bioinformatician in Multimodal Data Analysis of Organoids (f/m/d) to work in the field of analysis of 2D and 3D cellular models of liver, heart and brain derived from human pluripotent stem cells (hPSC). We are looking for a highly motivated dedicated candidate to work in the field of analysis of 2D and 3D cellular models of liver, heart and brain. The candidate will work for a central technology provision project in the Collaborative Research Centre/Transregio 296 LocoTact funded by the DFG. The LocoTact CRC-TR aims to dissect the local control of thyroid hormone action in physiology and pathophysiology (https://www.uni-due.de/crctr296/
). The interdisciplinary research consortium will take advantage of sophisticated in vitro tools such as 3D organoids derived from hPSC to facilitate the studies on the local control of thyroid hormone action in translationally relevant human model systems. The candidate will be expected set up state-of-the-art methods for analysis of 3D organoids (single cell RNA sequencing, 3D high content imaging).