Charité - Universitätsmedizin Berlin - Institute of Neurophysiology
The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.
Research Assistant (PhD Student in Neurophysiology)
In humans, slow-wave activity (SWA) is an indicator of adequate deep sleep, which is crucial for maintaining our cognitive abilities and overall health. In mammals, reptiles and even in the fruit fly Drosophila melanogaster SWA has been found to be a crucial component of regulating sleepiness and sleep depth, indicating that SWA represents an evolutionarily optimized strategy to regulate arousal and rest. However, the neural interactions that might represent the neuroanatomical foundation of sleep regulation are complex and far from understood. We are therefore looking for a PhD student who will use Drosophila to investigate the basic neural mechanisms that make animals tired, go to sleep and stay asleep.
Your area of responsibility:
To investigate the neural mechanism of sleep regulation, we will be using imaging techniques (voltage and Ca2+), electrophysiology and behavioral readouts in Drosophila to visualize neural activity patterns during sleep and awakening. The successfull PhD candidate will learn to master these techniques (not necessarily all) and learn how to independently conzeptualize and conduct a research project.
The research will take place at the Charité in Berlin, located at the center of the German capital. Berlin and the Charité offer an excellent scientific environment. The project will be performed in cooperation with the lab of David Owald, Stephan Sigrist and Mathias Wernet.
Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship.
We are looking for a highly motivated PhD student with a Master’s degree in Neuroscience or a related field. Ideally, the successful candidate has prior experience in either Drosophila genetics, in vivo preparations or electrophysiology. However, this is not a prerequisite. Proficiency in speaking and writing English is required.