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Offer 303 out of 583 from 05/05/22, 12:58

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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin - CC02, Department für Biochemie

Located in the heart of Berlin, Charité – Universitätsmedizin Berlin is one of Europe's largest and most research-intensive medical universities. The project is embedded in a collaboration between the group of Prof. Markus Ralser (Director of Institute of Biochemistry, Charité University Medicine) and two research groups at the University of Oxford, headed by Prof. Craig MacLean and Dr. Rachel Wheatley. This joint project addresses the role of bacterial-fungal co-infections in the evolution of antimicrobial resistance. This research effort is funded through the Berlin University Alliance and part of the Ox|Ber Oxford/Berlin Research Partnership, Centre for Advanced Studies. We are leaders in microbiology and metabolism research, employing large-scale, ultra-fast proteomics and evolutionary genomics to investigate antimicrobial resistance and tolerance mechanisms in bacterial and fungal pathogens.

Berlin-Oxford Centre for Advanced Studies
PhD Student - Microbiology, Systems Biology, Functional Omics

Charité Campus Mitte

Working field:

We are looking for a highly enthusiastic doctoral researcher to investigate the role of bacterial-fungal co-infections in the evolution of antimicrobial resistance (AMR), with particular focus on the multi-drug resistant bacterium Pseudomonas aeruginosa (PA) and the opportunistic fungal pathogen Candida albicans (CA). This position will be formally based at the Charité in Berlin, but part of the project will be conducted at the University of Oxford.

Your main tasks will be:
  • Adapting existing and developing improved experimental protocols for the high-throughput analysis of AMR in a CA-PA co-infection model
  • Determining the underlying mechanisms that alter stress tolerance in a CA-PA co-infection model;
  • Performing Adaptive Laboratory Evolution (ALE) and high-throughput proteomics experiments to monitor the emergence of tolerance and resistance in CA-PA communities;

You will get access to:
  • State-of-the-art research equipment and highly international and collaborative working environments both at the Charité - Universitätsmedizin Berlin and University of Oxford;
  • Extended stays at each academic institution:
o Opportunity to work in close contact with other basic- and clinical-research groups at Charité
in the heart of Germany's vibrant capital;
o Opportunity to work in close contact with other research groups within the Department of
Zoology at the University of Oxford, one of the world's leading research universities;
o Support from highly competent, experienced team members and potential to lead projects with
a high degree of academic freedom

Requirements:

Essential:
  • Master’s degree in natural sciences (Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, Bioinformatics/Computational Biology, or related fields)
  • Experience of designing and running experiments with microbial cultures (bacteria and/or fungi) in the laboratory
  • Hands-on experience with key biochemical and molecular biological methods
  • Motivation to work in an international research environment
Highly desirable:
  • Experience with and/or motivation to learn systems biology approaches, high-throughput methodologies,
  • Experience with and/or motivation to learn analytical and omics methods (LC-MS, NGS)
  • Basic ability to analyse data in R or Python
  • Good communication skills
Any of the following will be a plus:
  • Proficiency in data analysis using R
  • Interest in multispecies communities, host-pathogen interactions, or related topics
Working language is English. Applicants with multidisciplinary background or unusual career paths are also encouraged to apply.

How to apply:

Please send all application documents, e.g. cover letter, curriculum vitae, certificates, attestations, etc. to the following address, quoting the reference number

Charité - Universitätsmedizin Berlin
Campus Charité Mitte
CC02, Institut für Biochemie
Prof. Markus Ralser
Charitéplatz 1
10117 Berlin

Email address for sending the application documents:
bewerbungen-biochemie@charite.de

Details of contact person:
Prof. Markus Ralser
Tel: +49 30 450 528141
E-Mail: markus.ralser@charite.de