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Offer 270 out of 663 from 02/08/22, 12:41

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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin - Department of Pediatric Oncology and Hematology

The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.

Postdoc / Scientist

Charité Campus Virchow-Klinikum

Working field:

We offer an exciting position in the field of tumor immunology in a highly clinically relevant research area. Our current research focuses on identifying novel CAR targets as well as hurdles preventing CAR T cell success against solid tumors. Our mission is to advance CAR T technologies to raise therapeutic efficacy against solid tumors and to bring these advanced CAR T cell products to the patients.

  • Culturing of primary human and mouse T cells and tumor cells
  • Genetically engineering of primary human and mouse T cells with chimeric antigen receptors (CARs), dual CARs, and other chimeric molecules (Transduction / CRISPR)
  • Designing and cloning transgenes
  • Running flow cytometry analysis on tumor and T cells
  • Running ELISA / Westernblot / PCR analysis
  • Running immunohistochemistry or IF on tumor sections
  • Perform in vivo studies in mice
  • Analyzing data and presenting results at the lab meetings and conferences
  • Writing animal testing applications and project proposals
  • Responsible for S1 and S2 documentation
  • Supervision of (grad) students
  • Responsible of coordinating efficient laboratory operations, SOP validation and methodical quality control, keep accurate data records and notebooks, organize lab records, maintain inventories and perform other duties as assigned or directed in order to meet the goals and objectives of the lab.

Requirements:

  • PhD degree in Immunology, Cell Biology, Biomedicine or Biochemistry with outstanding result
  • In-depths experience in immunological techniques, molecular biology and immuno-oncology
  • Experience in next generation sequencing technologies (such as RNA-seq/ATAC-seq) is beneficial
  • Bioinformatics knowledge (e.g. NGS data analysis with R/python-based tools) is a plus
  • Enthusiasm for cell engineering and translational research
  • Excellent team spirit, presentation, scientific writing and communication skills.

Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship.

How to apply:

Please send all application documents, e.g. cover letter, curriculum vitae, certificates, attestations, etc. as PDF or image file to the following address, quoting the reference number:

Charité - Universitätsmedizin Berlin
PD Dr.med. Annette Künkele
Klinik für Pädiatrie m.S. Onkologie und Hämatologie
Augustenburger Platz 1, 13353 Berlin
Bitte Bewerbungen nur per email!

Email address for sending the application documents: annette.kuenkele@charite.de

Details of contact person: PD Dr. med. Annette Künkele - annette.kuenkele@charite.de