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Char­ité - Uni­versitätsmed­izin Ber­lin

The Char­ité - Uni­versitätsmed­izin Ber­lin is a joint med­ical fac­ulty, which serves both Freie Uni­versität Ber­lin and Hum­boldt Uni­versität zu Ber­lin. As one of the largest uni­versity hos­pit­als in Europe with an import­ant his­tory, it plays a lead­ing role in research, teach­ing and clin­ical care. The Char­ité uni­versity hos­pital has also made a name for itself as a mod­ern busi­ness with cer­ti­fic­a­tions in the med­ical, clin­ical and man­age­ment fields.

PhD

Depart­ment of Der­ma­to­logy, Ven­er­o­logy and Aller­go­logy

Work­ing field:

The research group Molecu­lar Immun­o­logy Char­ité (PI Pro­fessor Ghor­es­chi) works on inflam­mat­ory skin dis­eases, autoim­mune dis­eases and skin can­cer. Our team is formed by sci­ent­ists, phys­i­cians and bio­lo­gists. We focus on T cell immun­o­logy, cytokines and sig­nal­ing molecules rel­ev­ant for immune responses. In this pro­ject on pem­phigus, our goal is to identify the detailed immune response involved in the dis­eases to bet­ter under­stand under­ly­ing pathomech­an­isms and to identify new thera­peutic tar­gets.

The research group Molecu­lar Immun­o­logy Char­ité (PI Pro­fessor Ghor­es­chi, dir­ector of the Depart­ment for Der­ma­to­logy, Venere­ology and Aller­go­logy) is cur­rently look­ing for a PhD can­did­ate for a period of 3 years. The pro­ject is fun­ded by the Ger­man Research Soci­ety (DFG) and embed­ded in a national research con­sor­tium, which works on the under­stand­ing of pem­phi­gis and espe­cially the T/B-cell inter­ac­tions. The pro­ject will aim to indentify poten­tial thera­peutic tar­gets. We will use the fol­low­ing tech­no­lo­gies:
  • mouse mod­els and human 2D and 3D mod­els
  • cell cul­ture and func­tional assays of T/B cells from peri­pheral blood, ker­at­ino­cyte cul­tures
  • Flow-cyto­metry (FACS)
  • Mass spec­tro­metry (CyTOF and CyTOF ima­ging)
  • Immun­o­his­to­chem­istry and Immun­o­fluor­es­cence
  • Enzyme-linked Spot Assay (ELISPOT) and Enzyme-linked Immun­osorb­ent Assay (ELISA)
  • Isol­a­tion of nuc­leic acids from tis­sue and blood
  • quant­it­at­ive PCR
  • West­ern Blot
  • Mag­netic Cell Sep­ar­a­tion

Require­ments:

We are look­ing for a can­did­ate with a MSc or equal degree in bio­logy, bio­chem­istry or bios­ciences in gen­eral. The can­did­ate should have an excep­tional degree and should be inter­ested in the field of immun­o­logy. The can­did­ate should have prac­tical exper­i­ences in the wet lab and the fol­low­ing skills are highly appre­ci­ated:

  • exper­i­ence in work­ing with labor­at­ory anim­als
  • basic labor­at­ory skills
  • exper­i­ence in flow cyto­metry
  • know­ledge in ELISA tech­niques
  • exper­i­ence in qPCR

We are look­ing for a highly motiv­ated can­did­ate who likes to work in a team of phys­i­cians and sci­ent­ists. We expect the cap­ab­il­ity to inter­act with our col­lab­or­a­tion part­ners of the national con­sor­tium in a respect­ful and reli­able man­ner. We expect well com­mand of Eng­lish, orally and writ­ten.

What we of­fer:

DIE CHAR­ITÉ – UNI­VERSITÄTSMED­IZIN BER­LIN makes its human resources decisions based on suit­ab­il­ity, com­pet­ence and pro­fes­sional per­form­ance. At the same time, it strives to increase the per­cent­age of women in man­age­ment pos­i­tions and takes this into con­sid­er­a­tion where can­did­ates are equally qual­i­fied within the lim­its of what is leg­ally pos­sible. Applic­a­tions from people with a migrant back­ground are also expli­citly wel­come. Severely dis­abled applic­ants are given pref­er­en­tial con­sid­er­a­tion in the case of can­did­ates with equal qual­i­fic­a­tions. An exten­ded cer­ti­fic­ate of con­duct must be sub­mit­ted. Any travel expenses incurred can­not be reim­bursed.

Data pro­tec­tion notice: Char­ité points out that per­sonal data is stored and pro­cessed as part of the applic­a­tion pro­cess in dif­fer­ent areas of Char­ité (e.g. fac­ulty, staff com­mit­tee, human resources depart­ment). Fur­ther­more, the data may be trans­ferred or pro­cessed within the group as well as in loc­a­tions out­side the group (e.g. author­it­ies) to pro­tect legit­im­ate interests. By apply­ing, you agree to our data pro­tec­tion reg­u­la­tions and terms of use, which you can find here:

https://www.charite.de/service/datenschutz/bewerbungsverfahren/