The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.
Department of Dermatology, Venerology and Allergology
The research group Molecular Immunology Charité (PI Professor Ghoreschi) works on inflammatory skin diseases, autoimmune diseases and skin cancer. Our team is formed by scientists, physicians and biologists. We focus on T cell immunology, cytokines and signaling molecules relevant for immune responses. In this project on pemphigus, our goal is to identify the detailed immune response involved in the diseases to better understand underlying pathomechanisms and to identify new therapeutic targets.
The research group Molecular Immunology Charité (PI Professor Ghoreschi, director of the Department for Dermatology, Venereology and Allergology) is currently looking for a PhD candidate for a period of 3 years. The project is funded by the German Research Society (DFG) and embedded in a national research consortium, which works on the understanding of pemphigis and especially the T/B-cell interactions. The project will aim to indentify potential therapeutic targets. We will use the following technologies:
mouse models and human 2D and 3D models
cell culture and functional assays of T/B cells from peripheral blood, keratinocyte cultures
Mass spectrometry (CyTOF and CyTOF imaging)
Immunohistochemistry and Immunofluorescence
Enzyme-linked Spot Assay (ELISPOT) and Enzyme-linked Immunosorbent Assay (ELISA)
Isolation of nucleic acids from tissue and blood
Magnetic Cell Separation
We are looking for a candidate with a MSc or equal degree in biology, biochemistry or biosciences in general. The candidate should have an exceptional degree and should be interested in the field of immunology. The candidate should have practical experiences in the wet lab and the following skills are highly appreciated:
experience in working with laboratory animals
basic laboratory skills
experience in flow cytometry
knowledge in ELISA techniques
experience in qPCR
We are looking for a highly motivated candidate who likes to work in a team of physicians and scientists. We expect the capability to interact with our collaboration partners of the national consortium in a respectful and reliable manner. We expect well command of English, orally and written.
What we offer:
DIE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN makes its human resources decisions based on suitability, competence and professional performance. At the same time, it strives to increase the percentage of women in management positions and takes this into consideration where candidates are equally qualified within the limits of what is legally possible. Applications from people with a migrant background are also explicitly welcome. Severely disabled applicants are given preferential consideration in the case of candidates with equal qualifications. An extended certificate of conduct must be submitted. Any travel expenses incurred cannot be reimbursed.