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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin - Insti­tute of Phar­ma­co­logy - CC05

The Char­ité - Uni­versitätsmed­izin Ber­lin is a joint med­ical fac­ulty, which serves both Freie Uni­versität Ber­lin and Hum­boldt Uni­versität zu Ber­lin. As one of the largest uni­versity hos­pit­als in Europe with an import­ant his­tory, it plays a lead­ing role in research, teach­ing and clin­ical care. The Char­ité uni­versity hos­pital has also made a name for itself as a mod­ern busi­ness with cer­ti­fic­a­tions in the med­ical, clin­ical and man­age­ment fields.

PostDoc/Research Sci­ent­ist

Cha­rité Cam­pus Mitte

Work­ing field:

The AG Kintscher is work­ing on the rel­ev­ance of lipoly­sis for heart dis­ease aim­ing to develop new ther­apies for chronic heart fail­ure. We are an AG in the Insti­tute of Phar­ma­co­logy at Cam­pus Mitte and part of the Cen­ter for Car­di­ovas­cu­lar Research (CCR). The work in this pro­ject is part of a col­lab­or­a­tion with the Ein­stein BIH Vis­it­ing Fel­low Prof. Dr. Rudolf Zech­ner. Prof. Zech­ner is a highly respec­ted sci­ent­ist in the field of lipoly­sis. Pro­ject super­vi­sion will be ensured by Prof. Ulrich Kintscher and Prof. Zech­ner. The pro­ject invest­ig­ates the import­ance of adipose trigly­ceride lipase (ATGL) in endothelial cells for the devel­op­ment of chronic heart fail­ure. Our labor­at­ory is loc­ated on Cam­pus Mitte in the CCR at Hess­is­che Str. 3-4, 10115 Ber­lin.

Ihr Aufgabenge­biet:

We are look­ing for a highly motiv­ated postdoc­toral sci­ent­ist for an excit­ing pro­ject fun­ded by the Ein­stein Found­a­tion Ber­lin. The pro­ject is part of a col­lab­or­a­tion within the Ein­stein BIH Vis­it­ing Fel­low Pro­gram between Prof. Rudolf Zech­ner from Graz, Aus­tria, and Prof. Ulrich Kintscher from the Char­ité. The work is super­vised by both pro­fess­ors and car­ried out at the Insi­ti­tute for Phar­ma­co­logy of the Char­ité am Cam­pus Mitte. In this pro­ject, we want to demon­strate that ATGL-medi­ated lipoly­sis in endothelial cells has a sig­ni­fic­ant influ­ence on the devel­op­ment of heart fail­ure. For this pur­pose, animal exper­i­ments, cell bio­logy and molecu­lar bio­logy exper­i­ments are car­ried out.

  • The scope of this pro­ject includes animal stud­ies using mod­els of car­diac fail­ure includ­ing com­pre­hens­ive echo­car­di­o­graphic and micro CT-based ima­ging and invas­ive hemo­dy­nam­ics. In addi­tion, cell and tis­sue bio­lo­gical ana­lyzes of angiogen­esis and endothelial growth are per­formed. One focus is on meta­bolic pro­cesses in endothelial cells includ­ing the study of mito­chon­drial func­tion of endothelial cells.

  • with the pro­spect of par­ental leave replace­ment

Sci­entific staff is given suf­fi­cient time to carry out their own sci­entific work in accord­ance with their employ­ment rela­tion­ship.

Require­ments:

  • PhD / Dr. rer. nat in life or nat­ural sci­ences or sim­ilar qual­i­fic­a­tion
  • animal exper­i­ments, espe­cially with cre-lox sys­tems, small animal echo­car­di­o­graphy, invas­ive hemo­dy­nam­ics
  • know­ledge in the field of car­di­ovas­cu­lar dis­ease, in par­tic­u­lar heart fail­ure and / or know­ledge in the field of lipid / mito­chon­drial meta­bol­ism and / or know­ledge in the field of angiogen­esis
  • Exper­i­ences with cell bio­lo­gical ana­lyzes, in par­tic­u­lar with endothelial cells

How to ap­ply:

Please send all applic­a­tion doc­u­ments, e.g. cover let­ter, cur­riculum vitae, cer­ti­fic­ates, attest­a­tions, etc. to the fol­low­ing address, quot­ing the ref­er­ence num­ber

Char­ité - Uni­versitätsmed­izin Ber­lin
Insti­tut für Phar­mako­lo­gie
Hess­is­che Str. 3-4,
10115 Ber­lin

DIE CHAR­ITÉ – UNI­VERSITÄTSMED­IZIN BER­LIN makes its human resources decisions based on
suit­ab­il­ity, com­pet­ence and pro­fes­sional per­form­ance. At the same time, it strives to increase the per­cent­age of women in man­age­ment pos­i­tions and takes this into con­sid­er­a­tion where can­did­ates are equally qual­i­fied within the lim­its of what is leg­ally pos­sible. Applic­a­tions from people with a migrant back­ground are also expli­citly wel­come. Severely dis­abled applic­ants are given pref­er­en­tial con­sid­er­a­tion in the case of can­did­ates with equal qual­i­fic­a­tions. An exten­ded cer­ti­fic­ate of con­duct must be sub­mit­ted. Any travel expenses incurred can­not be reim­bursed.
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