Charité - Universitätsmedizin Berlin - Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry
The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.
In a project funded by the German Research Foundation (DFG) we intend to investigate protein tyrosine phosphatases (PTPs) as novel molecular targets of inflammation-mediated insulin resistance and skeletal muscle atrophy. The project is located at the interface between medicine, molecular biology, biochemistry and cell biology and represents a closely linked collaboration with the group of Prof. Fielitz, Universitätsmedizin Greifswald, Dept. of cardiology. The aim is to gain a better understanding of the role of PTPs in peripheral insulin resistance in skeletal muscle during sepsis or inflammation. The object of investigation is in particular the insulin signaling in the skeletal muscle. The project, located mainly at the Center for Cardiovascular Research of the Charité, offers the opportunity to work together in one of the best medical universities in Germany with numerous scientific cooperation possibilities. The preparation of a dissertation is desired and is supported (Dr. rer. nat., Dr. rer. medic.).
Your area of responsibility
handling of DNA, RNA and proteins
experimental analysis in cell culture
analyses in murine tissue and potentially animal experiments
planned publication of results in high-quality peer reviewed journals
attending institute-based scientific meetings
attending (international) scientific meetings and presenting results
Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship.
The candidate must have fully completed their master´s degree (or comparable) by the joining date of this project. Ideally, the studies were done in the field of biochemistry, biology, biotechnology, or pharmacy. Closely related fields are possible provided that all requirements, outlined in the areas of responsibility, are fulfilled. Ideally, the candidate has experience in experimental research and provides knowledge of the depicted methods. Some background knowledge in antibody/enzyme and further protein and DNA/RNA handling would be favorable. Analytical experiences in gel electrophoresis, western blotting, and PCR is of advantage.
The candidate must be able to work both independently and in a team and is interested in participating in the characterisation of cellular signalling pathways, and must be motivated to present the results of the project in publications. Since the project involves experiments with laboratory animals, it is necessary that you acknowledge the need for animal experiments for medical purposes. Apart from this, the ideal candidate is self-motivated and has an interest in working in an environment (Center for Cardiovascular Research at the Charité) with people from different nationalities.
How to apply:
Please send your application as a single PDF file of max. 5 MB quoting the reference numer to:
DIE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN makes its human resources decisions based on
suitability, competence and professional performance. At the same time, it strives to increase the percentage of women in management positions and takes this into consideration where candidates are equally qualified within the limits of what is legally possible. Applications from people with a migrant background are also explicitly welcome. Severely disabled applicants are given preferential consideration in the case of candidates with equal qualifications. An extended certificate of conduct must be submitted. Any travel expenses incurred cannot be reimbursed.